Triple Vino Circulation is a dietary supplement containing 3 vine extracts (Vitis vinifera), standardized in active ingredients.
Benefits of our Red Vine Supplement
The 3 ingredients in Triple Vino Circulation may have antioxidant properties and may maintain already healthy cardiovascular system* (1-3).
Specifically, the supplement contains:
- An extract of red vine leaf: red vine leaf may be major source of flavonoids and other antioxidant polyphenols, which may help protect cells and tissues from oxidative stress*. The bioflavonoids in this plant may maintain circulation, reducing the permeability and improving blood vessel resistance*. Red vine may help maintain already healthy blood pressure* (4-8).
- An extract of grape seed: grape seeds may also be a well-known source of antioxidants, especially proanthocyanidins (including oligo-proanthocyanidins or OPCs), and may supposedly maintain cellular health*. Grape seeds may also promote healthy blood vessels, as their various antioxidants may help protect the endothelium (the inner lining of blood vessels) and their OPCs may promote nitric oxide production which may relax blood vessels and improve circulation* (9-10).
- An extract of grape marc: grape marc, or pomace, refers to the solid residues collected after the grapes have been pressed, and consists of the skin, seeds, and stalks of the fruit. Rich in OPCs and anthocyanins, grape marc may also have antioxidant properties. It may also help with weight loss and control of cellulite* (11-14).
3 Strengths of the Supplement Triple Vino Circulation
Our supplement is notable in 3 specific respects:
- Parts of the vine naturally rich in polyphenols: each of the 3 extracts come from parts of the vine abundant in polyphenols, some of the most powerful natural antioxidants produced by plants. These polyphenols include bioflavonoids, OPCs, anthocyanins, etc.
- 3 extracts standardized in active ingredients: the most effective polyphenols in our extracts are present at high, optimal levels. Red vine leaf extract is standardized to 10% polyphenols and 4% bioflavonoids; grape seed extract to 95% polyphenols, 70% proanthocyanidins, and 40% OPCs; and grape marc extract to 95% polyphenols, 30% OPCs, and 2% anthocyanins, to bring you the very best of the grapevine.
- A dose that is both safe and effective: a daily dose (2 capsules) of Triple Vino Circulation provides 500 mg of red vine leaf extract, 165 mg of grape seed extract, and 165 mg of grape marc extract. This precise dosage has been calculated to ensure the supplement delivers both unparalleled efficacy and maximum safety.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
WARNINGS
Do not exceed the recommended daily dose. This product is a nutritional supplement and should not be used as a substitute for a varied and balanced diet or a healthy lifestyle.
STORAGE
Store in a cool, dry place away from direct sunlight, heat, and humidity.
Keep out of reach of children.
PREGNANCY AND MEDICAL CONDITIONS
If you are pregnant, breastfeeding, or have any medical conditions, consult your healthcare provider before using this product.
SUPPLEMENT INTERACTIONS
Consult your healthcare provider before use, especially if you are taking any medications or other supplements as there may be potential interactions.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Daily dose: 2 capsules
Number of doses per pack: 30
Vine extracts (Vitis vinifera): |
Amount per dose |
| Extract of red vine leaf standardized to 10% polyphenols and 4% bioflavonoids |
500 mg |
| Extract of grape seed standardized to 95% polyphenols, 70% proanthocyanidins, and 40% OPCs |
165 mg |
| Extract of grape marc standardized to 95% polyphenols, 30% OPCs, and 2% anthocyanins |
165 mg |
| Other ingredient: acacia gum.
|
Recommended dose: take 2 vegetarian capsules a day with meals. Each capsule contains 250 mg of red vine leaf extract, 82.5 mg of grape seed extract, and 82.5 mg of grape marc extract.
Duration: 30 days.
Storage: store away from heat, light, and humidity.
Precautions: for adults. Do not exceed the recommended daily dose. This product is a nutritional supplement which should not be used as a substitute for a varied, balanced diet or healthy lifestyle. Keep out of young children’s reach. Store away from light, heat, and humidity. As with all nutritional supplements, consult a healthcare professional before taking if you are pregnant, breastfeeding, or have a health condition.
- Rabe E, Stücker M, Esperester A, Schäfer E, Ottillinger B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur J Vasc Endovasc Surg. 2011 Apr;41(4):540-7. doi: 10.1016/j.ejvs.2010.12.003. Epub 2011 Jan 15. PMID: 21239190.
- Jung HJ, Choo KS. Pilot study on the effect of grape seed proanthocyanidin extract on inferior vene cava blood flow in patients with chronic venous insufficiency using 4D flow MRI. Medicine (Baltimore). 2022 Nov 18;101(46):e31792. doi: 10.1097/MD.0000000000031792. PMID: 36401399; PMCID: PMC9678586.
- Bocsan IC, Măgureanu DC, Pop RM, Levai AM, Macovei ȘO, Pătrașca IM, Chedea VS, Buzoianu AD. Antioxidant and Anti-Inflammatory Actions of Polyphenols from Red and White Grape Pomace in Ischemic Heart Diseases. Biomedicines. 2022 Sep 20;10(10):2337. doi: 10.3390/biomedicines10102337. PMID: 36289599; PMCID: PMC9598344.
- https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-vitis-vinifera-l-folium-revision-1_en.pdf
- Rabe E, Stücker M, Esperester A, Schäfer E, Ottillinger B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur J Vasc Endovasc Surg. 2011 Apr;41(4):540-7. doi: 10.1016/j.ejvs.2010.12.003. Epub 2011 Jan 15. PMID: 21239190.
- Kiesewetter H, Koscielny J, Kalus U, Vix JM, Peil H, Petrini O, van Toor BS, de Mey C. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung. 2000 Feb;50(2):109-17. doi: 10.1055/s-0031-1300174. PMID: 10719612.
- Stücker M, Rabe E, Meyer K, Ottillinger B, Schütt T. Therapeutic approach to chronic venous insufficiency - clinical benefits of red-vine-leaf-extract AS 195 (Antistax®). Pharmazie. 2019 Apr 1;74(4):193-200. doi: 10.1691/ph.2019.9326. PMID: 30940301.
- https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-vitis-vinifera-l-folium-revision-1_en.pdf
- Gupta M, Dey S, Marbaniang D, Pal P, Ray S, Mazumder B. Grape seed extract: having a potential health benefits. J Food Sci Technol. 2020 Apr;57(4):1205-1215. doi: 10.1007/s13197-019-04113-w. Epub 2019 Sep 30. PMID: 32180617; PMCID: PMC7054588.
- Jung HJ, Choo KS. Pilot study on the effect of grape seed proanthocyanidin extract on inferior vene cava blood flow in patients with chronic venous insufficiency using 4D flow MRI. Medicine (Baltimore). 2022 Nov 18;101(46):e31792. doi: 10.1097/MD.0000000000031792. PMID: 36401399; PMCID: PMC9678586.
- Sri Harsha PSC, Lavelli V. Use of Grape Pomace Phenolics to Counteract Endogenous and Exogenous Formation of Advanced Glycation End-Products. Nutrients. 2019 Aug 15;11(8):1917. doi: 10.3390/nu11081917. PMID: 31443235; PMCID: PMC6723612.
- Taladrid D, Rebollo-Hernanz M, Martin-Cabrejas MA, Moreno-Arribas MV, Bartolomé B. Grape Pomace as a Cardiometabolic Health-Promoting Ingredient: Activity in the Intestinal Environment. Antioxidants (Basel). 2023 Apr 21;12(4):979. doi: 10.3390/antiox12040979. PMID: 37107354; PMCID: PMC10135959.
- Bocsan IC, Măgureanu DC, Pop RM, Levai AM, Macovei ȘO, Pătrașca IM, Chedea VS, Buzoianu AD. Antioxidant and Anti-Inflammatory Actions of Polyphenols from Red and White Grape Pomace in Ischemic Heart Diseases. Biomedicines. 2022 Sep 20;10(10):2337. doi: 10.3390/biomedicines10102337. PMID: 36289599; PMCID: PMC9598344.
- Chedea VS, Macovei ȘO, Bocșan IC, Măgureanu DC, Levai AM, Buzoianu AD, Pop RM. Grape Pomace Polyphenols as a Source of Compounds for Management of Oxidative Stress and Inflammation-A Possible Alternative for Non-Steroidal Anti-Inflammatory Drugs? Molecules. 2022 Oct 12;27(20):6826. doi: 10.3390/molecules27206826. PMID: 36296420; PMCID: PMC9612310.
- https://www.vidal.fr/parapharmacie/phytotherapie-plantes/vigne-rouge-vitis-vinifera-tinctoria.html#:~:text=La%20dur%C3%A9e%20de%20traitement%20recommand%C3%A9e,pour%20ressentir%20ses%20effets%20b%C3%A9n%C3%A9fiques.
- https://www.vidal.fr/parapharmacie/phytotherapie-plantes/vigne-rouge-vitis-vinifera-tinctoria.html#:~:text=Les%20seuls%20effets%20ind%C3%A9sirables%20signal%C3%A9s,une%20allergie%20de%20la%20peau.
- Rabe E, Stücker M, Esperester A, Schäfer E, Ottillinger B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur J Vasc Endovasc Surg. 2011 Apr;41(4):540-7. doi: 10.1016/j.ejvs.2010.12.003. Epub 2011 Jan 15. PMID: 21239190.
- https://www.vidal.fr/parapharmacie/phytotherapie-plantes/vigne-rouge-vitis-vinifera-tinctoria.html#:~:text=Les%20seuls%20effets%20ind%C3%A9sirables%20signal%C3%A9s,une%20allergie%20de%20la%20peau.
