Trigonelline is a dietary supplement containing trigonelline, a naturally occurring alkaloid currently being studied in relation to cellular metabolism, healthy aging, and overall wellness research.*
Introduced by a European brand, our trigonelline formula provides 300 mg per daily serving with a tested purity of 98%.
Trigonelline is included in our Healthy Aging category.
What is Trigonelline?
A naturally occurring botanical compound
Trigonelline is a naturally occurring alkaloid also known as N-methylnicotinic acid.*
It is naturally present in coffee beans, fenugreek seeds, and various plant sources.*
Trigonelline is also related to vitamin B3 (niacin) metabolism and continues to attract scientific interest in the field of cellular wellness research.*
Why is trigonelline being studied?
Recent scientific interest has focused on trigonelline in relation to cellular metabolism, healthy aging, and overall vitality research.*
Research is currently exploring its interactions with pathways associated with cellular energy and metabolic processes, though further studies are needed.*
Characteristics of Our Trigonelline Formula
Our trigonelline supplement has several distinctive features:
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Provides 300 mg of trigonelline hydrochloride per daily serving.*
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Features a highly purified form standardized to 98% purity.*
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Developed in convenient vegetable pullulan capsules.*
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Formulated with a limited number of ingredients, including acacia gum as an excipient.*
Additional Formula Information
Unlike many botanical extracts naturally containing low amounts of trigonelline, this formula provides a concentrated and standardized source of the compound.
The formula is designed with vegetable capsules and without controversial excipients.
WARNINGS
Do not exceed the recommended daily dose. This product is a nutritional supplement and should not be used as a substitute for a varied and balanced diet or a healthy lifestyle.
STORAGE
Store in a cool, dry place away from direct sunlight, heat, and humidity.
Keep out of reach of children.
PREGNANCY AND MEDICAL CONDITIONS
If you are pregnant, breastfeeding, or have any medical conditions, consult your healthcare provider before using this product.
SUPPLEMENT INTERACTIONS
Consult your healthcare provider before use, especially if you are taking any medications or other supplements as there may be potential interactions.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Daily dose: 2 capsules
Number of doses per bottle: 30
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Daily dose
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Trigonelline hydrochloride
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300 mg
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Other ingredients: acacia gum, pullulan capsule.
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Serving size: Take 2 capsules a day with a meal. Each capsule contains 150 mg trigonelline hydrochloride.
Servings per container: 30
Storage: Store away from direct light, heat, and humidity.
Cautions: For adults only. Do not exceed the recommended daily dose. Keep out of reach of children. Consult a healthcare provider before taking this supplement and if you are pregnant, breastfeeding, or having health concerns.*
This product is a dietary supplement and should not be used as a substitute for a varied, balanced diet and a healthy lifestyle.
- National Center for Biotechnology Information (2026). PubChem Compound Summary for CID 5570, Trigonelline. Retrieved April 8, 2026 from https://pubchem.ncbi.nlm.nih.gov/compound/Trigonelline.
- Membrez M, Migliavacca E, Christen S, Yaku K, Trieu J, Lee AK, Morandini F, Giner MP, Stiner J, Makarov MV, Garratt ES, Vasiloglou MF, Chanvillard L, Dalbram E, Ehrlich AM, Sanchez-Garcia JL, Canto C, Karagounis LG, Treebak JT, Migaud ME, Heshmat R, Razi F, Karnani N, Ostovar A, Farzadfar F, Tay SKH, Sanders MJ, Lillycrop KA, Godfrey KM, Nakagawa T, Moco S, Koopman R, Lynch GS, Sorrentino V, Feige JN. Trigonelline is an ... . Nat Metab. 2024 Mar;6(3):433-447. doi: 10.1038/s42255-024-00997-x. Epub 2024 Mar 19. PMID: 38504132; PMCID: PMC10963276.
- Lv W, Cao D, Yang F. Trigonelline ... Pathway. Physiol Res. 2025 Jul 23;74(3):439-447. doi: 10.33549/physiolres.935486. PMID: 40698661; PMCID: PMC12462706.
- Paleerath Peerapen, Wanida Boonmark, Suwichaya Chantarasaka, Visith Thongboonkerd,
Trigonelline ... EA.hy926 cells, Biomedicine & Pharmacotherapy, Volume 179, 2024, 117320, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2024.117320.
- Zhang F, Yue H, Dong R, He J, Zhou L, Dou X, Wang L, Zheng P, Mao Z, Zhu X, Wang Y, Liu H, Zhang H. Trigonelline ... . Respir Res. 2024 Jun 15;25(1):242. doi: 10.1186/s12931-024-02876-1. PMID: 38877465; PMCID: PMC11179236.
- Lv W, Cao D, Yang F. Trigonelline ... 1 Pathway. Physiol Res. 2025 Jul 23;74(3):439-447. doi: 10.33549/physiolres.935486. PMID: 40698661; PMCID: PMC12462706.
- Qiu Z, Ma J, Zhang X, Jiao M, Zhi L. Electroacupuncture combined with trigonelline ... pathway. Brain Res Bull. 2025 Feb;221:111200. doi: 10.1016/j.brainresbull.2025.111200. Epub 2025 Jan 7. PMID: 39788460.
- Sekhar MG, Ramudu Shanmugam K, Chakrapani IS. Trigonelline, a Fenugreek Bioactive compound ... perspective. J Ayurveda Integr Med. 2024 Jul-Aug;15(4):100963. doi: 10.1016/j.jaim.2024.100963. Epub 2024 Aug 7. PMID: 39116705; PMCID: PMC11350489.
- Membrez M, Migliavacca E, Christen S, Yaku K, Trieu J, Lee AK, Morandini F, Giner MP, Stiner J, Makarov MV, Garratt ES, Vasiloglou MF, Chanvillard L, Dalbram E, Ehrlich AM, Sanchez-Garcia JL, Canto C, Karagounis LG, Treebak JT, Migaud ME, Heshmat R, Razi F, Karnani N, Ostovar A, Farzadfar F, Tay SKH, Sanders MJ, Lillycrop KA, Godfrey KM, Nakagawa T, Moco S, Koopman R, Lynch GS, Sorrentino V, Feige JN. Trigonelline is an ... . Nat Metab. 2024 Mar;6(3):433-447. doi: 10.1038/s42255-024-00997-x. Epub 2024 Mar 19. PMID: 38504132; PMCID: PMC10963276.
