L-selenomethionine is a single chemical entity containing molecularly integrated selenium instead of sulfur in the methionine molecule - methionine being an essential amino acid. It is therefore a particularly safe form of selenium supplementation because, unlike other forms, it does not release inorganic selenium into the body.
You can buy L-selenomethionine at SuperSmart.
What is Selenomethionine?
Plants absorb selenium from the soil and convert it into organic forms. Selenium is therefore found as selenomethionine in wheat and other cereals and is thus also the main type of selenium present in foods. When ingested in this form, it replaces the sulfur in proteins, both in animals and humans. Selenomethionine is also the main form in which the body stores selenium. It is directly incorporated into proteins via metabolic pathways similar to those used by methionine. It is converted into selenocysteine, and then incorporated into selenoproteins.
The replacement of methionine by selenomethionine in the protein structure does not induce any functional changes. In fact, selenium in the protein structure protects DNA from oxidation more effectively than the sulfur in methionine. During photochemical reactions, the carbon-selenium bond is more easily broken compared to the carbon-sulfur bond. L-seleno-methionine preferentially accepts the energy from light and provides greater protection to the skin against UV damage.
What is the Benefit of Using L-Selenomethionine?
The form of selenomethionine that the body is able to use is L-selenomethionine. It is absorbed and incorporated into the body's components better than any other form of selenium. Its superior bioavailability has been demonstrated in several studies: selenium levels in red blood cells of individuals receiving selenomethionine increased by 100% after 16 weeks' supplementation, bringing more health benefits. Neither selenate nor selenite supplementation produced such an increase.
Led by the US National Cancer Institute, the Selenium and Vitamin E Cancer Prevention Trial is an ongoing study using L-selenomethionine. Launched in 2001, the 12-year study involves 35,000 men in the US, Canada, and Puerto Rico and is investigating how selenium and vitamin E may protect against prostate cancer.
Buy L-selenomethionine today and benefit from its superior bioavailability.
WARNINGS
Do not exceed the recommended daily dose. This product is a nutritional supplement and should not be used as a substitute for a varied and balanced diet or a healthy lifestyle.
STORAGE
Store in a cool, dry place away from direct sunlight, heat, and humidity.
Keep out of reach of children.
PREGNANCY AND MEDICAL CONDITIONS
If you are pregnant, breastfeeding, or have any medical conditions, consult your healthcare provider before using this product.
SUPPLEMENT INTERACTIONS
Consult your healthcare provider before use, especially if you are taking any medications or other supplements as there may be potential interactions.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Daily serving: 1 tablet
Number of servings per bottle: 120 |
Quantity per serving |
L-selenomethionine providing 200 mcg of elemental selenium |
480 mcg |
Other ingredients: acacia gum, fructo-oligosaccharides.
RDA in selenium: 363%. |
In this form, the most abundant in food, selenium is rapidly and completely absorbed by the gastro-intestinal system.
Adults: Take 1 tablet a day with food.
Precautions: do not exceed the recommended daily dose. This product is a nutritional supplement and should not be used as a substitute for a varied, balanced diet or a healthy lifestyle. Keep out of children’s reach. Store away from light, heat, and humidity. As with any nutritional supplement, consult a health care practitioner before use if you are pregnant, breastfeeding, or have a medical condition.
- National Center for Biotechnology Information (2022). PubChem Compound Summary for CID 105024, L-selenomethionine. Retrieved May 6, 2022 from https://pubchem.ncbi.nlm.nih.gov/compound/L-selenomethionine.
- Schrauzer GN. Selenomethionine: a review of its nutritional significance, me-tabolism and toxicity. J Nutr. 2000 Jul;130(7):1653-6. doi: 10.1093/jn/130.7.1653. PMID: 10867031.
- Bera S, De Rosa V, Rachidi W, Diamond AM. Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemopreven-tion?. Mutagenesis. 2013;28(2):127-134. doi:10.1093/mutage/ges064
- Overvad K, Thorling EB, Bjerring P, Ebbesen P. Selenium inhibits UV-light-induced skin carcinogenesis in hairless mice. Cancer Lett. 1985 Jun;27(2):163-70. doi: 10.1016/0304-3835(85)90105-3. PMID: 4005828.
- Hall JA, Van Saun RJ, Bobe G, Stewart WC, Vorachek WR, Mosher WD, Ni-chols T, Forsberg NE, Pirelli GJ. Organic and inorganic selenium: I. Oral bioa-vailability in ewes. J Anim Sci. 2012 Feb;90(2):568-76. doi: 10.2527/jas.2011-4075. Epub 2011 Sep 30. PMID: 21965451.
- Schrauzer GN. Selenomethionine: a review of its nutritional significance, me-tabolism and toxicity. J Nutr. 2000 Jul;130(7):1653-6. doi: 10.1093/jn/130.7.1653. PMID: 10867031.
- Fairweather-Tait SJ, Collings R, Hurst R. Selenium bioavailability: current knowledge and future research requirements. Am J Clin Nutr. 2010 May;91(5):1484S-1491S. doi: 10.3945/ajcn.2010.28674J. Epub 2010 Mar 3. Erratum in: Am J Clin Nutr. 2010 Oct;92(4):1002. PMID: 20200264.
- Huang Z, Rose AH, Hoffmann PR. The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2012;16(7):705-743. doi:10.1089/ars.2011.4145
- Arteel GE, Sies H. The biochemistry of selenium and the glutathione system. Environ Toxicol Pharmacol. 2001 Sep;10(4):153-8. doi: 10.1016/s1382-6689(01)00078-3. PMID: 21782571
- Combs GF Jr, Midthune DN, Patterson KY, et al. Effects of se-lenomethionine supplementation on selenium status and thyroid hormone concentrations in healthy adults. Am J Clin Nutr. 2009;89(6):1808-1814. doi:10.3945/ajcn.2008.27356
- Moslemi MK, Tavanbakhsh S. Selenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate. Int J Gen Med. 2011;4:99-104. Published 2011 Jan 23. doi:10.2147/IJGM.S16275
- Tortelly Costa VD, Melo DF, Matsunaga AM. The Relevance of Se-lenium to Alopecias. Int J Trichology. 2018;10(2):92-93. doi:10.4103/ijt.ijt_37_17
- Shreenath AP, Ameer MA, Dooley J. Selenium Deficiency. [Updated 2021 Dec 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Pu-blishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482260/
- MacFarquhar JK, Broussard DL, Melstrom P, et al. Acute selenium toxi-city associated with a dietary supplement. Arch Intern Med. 2010;170(3):256-261. doi:10.1001/archinternmed.2009.495
- MacFarquhar JK, Broussard DL, Melstrom P, et al. Acute selenium toxi-city associated with a dietary supplement. Arch Intern Med. 2010;170(3):256-261. doi:10.1001/archinternmed.2009.495
- Amraoui W, Adjabi N, Bououza F, et al. Modulatory Role of Selenium and Vitamin E, Natural Antioxidants, against Bisphenol A-Induced Oxidative Stress in Wistar Albinos Rats. Toxicol Res. 2018;34(3):231-239. doi:10.5487/TR.2018.34.3.231
- Singh U, Devaraj S, Jialal I. Vitamin E, oxidative stress, and inflamma-tion. Annu Rev Nutr. 2005;25:151-74. doi: 10.1146/annurev.nutr.24.012003.132446. PMID: 16011463.
- Marreiro DD, Cruz KJ, Morais JB, Beserra JB, Severo JS, de Oliveira AR. Zinc and Oxidative Stress: Current Mechanisms. Antioxidants (Basel). 2017 Mar 29;6(2):24. doi: 10.3390/antiox6020024. PMID: 28353636; PMCID: PMC5488004.
- Maares M, Haase H. Zinc and immunity: An essential interrelation. Arch Biochem Biophys. 2016 Dec 1;611:58-65. doi: 10.1016/j.abb.2016.03.022. Epub 2016 Mar 26. PMID: 27021581.
- Park H, Kim CW, Kim SS, Park CW. The therapeutic effect and the changed serum zinc level after zinc supplementation in alopecia areata pa-tients who had a low serum zinc level. Ann Dermatol. 2009;21(2):142-146. doi:10.5021/ad.2009.21.2.142