DAILY 3 MULTIVITAMIN SUPPLEMENT - FIGHTS TIREDNESS AND LACK OF ENERGY

If you could only take one dietary supplement, it should be this one. Daily 3® is an exceptional multivitamin supplement in vegetarian capsules containing no less than 42 ingredients (including 12 vitamins, 8 minerals and a number of premium phytonutrients).

It is regularly rated as one of the best multivitamins available as it provides amazing value for what it cost. It is constantly updated and improved to reflect the latest scientific advances. It has a high quality of content, as well as patented ingredients, including BioPQQ®, Quatrefolic® and Bioperine®.

It was recently updated again in June 2019 to provide an unprecedented level of excellence.

What is it that makes Daily 3® the ultimate daily vitamin supplement?

Those who have tried Daily 3® know it’s not like other multivitamin supplements. The many advantages it offers raise it to a whole new level and produce rapid benefits. They include:

• A new, increased dose of BioPQQ®. PQQ is a quinone disodium salt obtained naturally through fermentation and is considered to be one of the best of the antioxidant vitamin compounds.Studies show it helps increase short-term performance and maintain long-term cognitive health by supporting the production of new mitochondria. There are only a handful of supplements that contain PQQ at this level.
• The presence of nicotinamide mononucleotide (NMN), a highly-prized anti-aging ingredient. This is the most direct precursor of the coenzyme nicotinamide adenine dinucleotide (NAD). Studies show that decreasing production of it irreversibly contributes to aging and declining health. The ease with which it crosses the intestinal barrier to be converted into NAD is the reason it’s considered to be one of the most promising anti-aging supplement ingredients.
• Unlike the majority of multivitamins, Daily 3® does not contain copper or iron, as these minerals have been studied to have pro-oxidant effects for people who already have adequate levels.
• It contains remarkable amounts of Vitamin D3 for a multivitamin and mineral supplement (1000 IU per 3-capsule dose, which is 100 % of the recommended daily amount). And, in addition to the many Vitamin D3 benefits, there are very few Vitamin D3 side effects to worry about.
• Daily 3® also contains natural extracts and premium antioxidant phytonutrients such as rutin, lutein, lycopene, OPCs, astaxanthin, luteolin, quercetin and apigenin, as well as appropriate amino acids, such as taurine and N-acetyl-cysteine. Each helps reduce the risk of certain diseases and improves symptoms of the most common health problems — hypertension, elevated blood glucose, venous insufficiency, high cholesterol and declining energy production.
• The icing on the cake is the addition of Bioperine®, a patented ingredient obtained from black pepper, which increases the bioavailability of many micronutrients, including vitamin B6, vitamin C and selenium.

For each micronutrient, Supersmart has used the latest scientific data to select the most suitable forms, ensuring high bioavailability and a low risk of side effects.

The vitamin B9 used is a patented form — Quatrefolic® — crowned ‘Product of the Year’ at the NutraIngredients Awards 2016, which offers maximum bioavailability due to unparalleled solubility and stability. The magnesium is a chelated form which uses transport proteins to cross the cell membrane. The zinc gluconate is the form most widely recommended for preventing the common cold, the niacinamide form of Vitamin B3 is the only one that doesn’t cause flushing of the skin, and the Vitamin E is natural source, as it’s the form the body uses most effectively. Nothing has been left to chance.

Nothing in Supersmart's Daily 3® multivitamin is included ‘just for show.’ All the ingredients in Daily 3® have been selected at appropriate doses. The levels of vitamins and minerals are all close to the recommended daily amounts — and sometimes higher —when such levels have been identified by scientific literature as beneficial to your health. But in no case are they anywhere near the maximum amount tolerable, above which there’s a risk to health. Most multivitamin manufacturers add ingredients in token amounts simply ‘for show,’ but this is categorically not the case with Daily 3®.

What are all the benefits can you expect to see from supplementing with Daily 3?

A study has shown that more than 80% of American doctors and health professionals take a daily multivitamin and mineral supplement. This is hardly surprising given that this group of individuals is particularly well informed when it comes to nutrition.

With its wide range of ingredients, Daily 3® multivitamin supplement offers innumerable health benefits. It specifically helps:

• Reduce the risk of disease and infection.
• Protect cells against oxidative stress, which contributes to the aging process.
• Enhance visual and nervous system function.
• Support production of blood cells, collagen and thyroid hormone.
• Optimize fertility and reproduction.
• Maintain the health of bones, hair, skin, teeth and blood vessels.
• Normalize blood sugar and cholesterol levels, as well as digestion.
• Boost and re-energize the body while reducing physical and mental fatigue.
• Optimize the immune system.

With such diverse advantages, you can buy Daily 3® as a simple and effective way of maintaining and improving your health over the long term.

What exactly are the latest changes to Daily 3®?

Daily 3® composition was updated in June 2019. The new formula was designed to push the boundaries of excellence even further and incorporate the latest scientific advances.

What’s been added

For the first time, we have added nicotinamide mononucleotide.
The addition of nicotinamide mononucleotide to Daily 3® (10mg per daily dose) is a major development given this compound’s reputation in medical science. Studies show it’s a highly promising anti-aging substance that is only just starting to be available to the public. Once ingested, it crosses the intestinal barrier with ease, where it is converted into an essential coenzyme called NAD (nicotinamide adenine dinucleotide), the production of which declines with age. It’s clear NAD helps fight against aging by increasing the level of sirtuins — the ‘longevity proteins’ — involved in many physiological mechanisms.

The amount of BioPQQ® has been doubled and that of lycopene increased from 2 to 5 mg.
Studies show that PQQ stimulates the growth of new mitochondria, the organelles responsible for cellular energy production, as well as nerve growth factor (NGF). One clinical study demonstrated that 8 weeks supplementing with PQQ led to improvements in mood, fatigue, and sleep quality. In this new version of Daily 3®, Supersmart has increased PQQ levels to 10 mg, in line with the dose used in studies.

The amount of magnesium has been doubled.
A recent study showed one in two of us has inadequate magnesium levels. This is a growing trend due to rapid changes in dietary habits, greater stress levels, increasingly common disruption of the acid-base balance, and the rising incidence of diseases like diabetes and metabolic syndrome. The consequences of such inadequacy are far from trivial: nerve and muscle hyperexcitability, cramps, tingling, hypersensitivity to stress, insomnia, increased heart rate, more frequent migraines, emotional oversensitivity, fatigue, and muscle pain. This is why we doubled the amount of magnesium in our multivitamin supplement, increasing the total daily dose to 80 mg.

What’s been improved

Resveratrol has been replaced by pterostilbene.
Daily 3® now features pterostilbene, a nutrient from the same family as resveratrol but with much better bioavailability (80% for pterostilbene as against 20% for resveratrol).

It now contains a better form of Vitamin B6.
Scientists have recently demonstrated that the active form of vitamin B6 in the body is pyridoxal-5-phosphate. Pyridoxine has therefore been replaced by this more bioavailable form.

Vitamin K1 has been reduced from 140 µg to 100 µg and 75 µg of Vitamin K2 has been added.
There are two main forms of Vitamin K: phytomenadione (K1) and menaquinone (K2). Recent studies suggest Vitamin K1 acts more directly on coagulation, while other studies show that K2 works on the calcification of soft tissue. That’s why it makes sense to offer both forms in our formulation.

What’s been reduced or removed

The amount of Vitamin A is now lower.
As recent studies have shown that the risk of vitamin A deficiency in developed countries is now low, Supersmart has reduced the amount of this in our multivitamin supplement to make room for other beneficial nutrients. It’s important to note, however, that the previous version never presented any risk of ‘overdosing,’ as beta-carotene is only converted into vitamin A when the body needs it.

Total tocopherols and gamma tocopherols have been removed.
Some meta-analyses have questioned the wisdom of regular supplementation with Vitamin E at doses above 400 IU a day. For those with very low starting levels of oxidative stress, it could actually present a slight health risk. While such conclusions remain the subject of debate, Supersmart has chosen to remove the synthetic tocopherols from Daily 3® and retain only the natural Vitamin E and tocotrienols.

Molybdenum, selenium and zinc have all been reduced.
We’ve chosen to reduce the amount of these three trace elements and bring them in line with recommended daily amounts since the latest studies have shown no benefit in exceeding these levels. We have, of course, retained the same exceptional forms which offer optimal bioavailability: molybdenum citrate, selenomethionine — obtained naturally — and zinc gluconate.

Three good reasons to take Daily 3® multivitamins every day

Daily 3® makes it easy to maintain your health. Here are three of the biggest reasons to take it daily:

1. To extend your life expectancy. As you’re no doubt aware, healthy life expectancy or ‘healthspan’ has stopped rising in Western countries. Many physiological mechanisms become less efficient with age, such as absorption of nutrients through the digestive wall, production of endogenous antioxidants, and efficacy of the immune system, neurotransmission, and circulation. Relatively quickly, this degeneration leads to the development of age-related diseases and makes the body more fragile. The composition of Daily 3® has been developed to combat the decline in these functions and compensate for their loss of efficacy.
2. To allow your body to realize its full potential and help you feel great. Even if you eat a balanced, organic diet, you’ll almost certainly still be lacking in several micronutrients. The nutrient and mineral content of our food has been in constant decline the past century and our fruit and vegetable intake is generally far from ideal. Researchers have estimated the loss in calcium, iron, Vitamin B12 and Vitamin C to be approximately 30% in the past 50 years. This is due to the misuse of pesticides, soil depletion, the preference for more resistant, but less nutritious, varieties, eating foods that spend days in transit before being stored, and modern lifestyles. Daily 3® allows you to compensate for these losses.
3. To combat the relentless attack on your body from the pollution, harmful substances and stress that cause disease. In the West, we’re facing an epidemic of ‘new’ disorders and health problems, such as diabetes and obesity, as well as auto-immune and neurodegenerative diseases. These are all linked, either directly or indirectly, to our unhealthy new dietary model, increasingly sedentary lifestyles and raised stress levels, all of which increase our requirements for many nutrients, particularly vitamins that contain antioxidants. With its high content of exceptional antioxidants and vitamins in optimal forms, Daily 3® helps the body combat these attacks and reduces the risk of many common conditions and diseases.

There’s a reason Daily 3® has been cited as one of the best daily vitamins for women and also one of the best daily vitamins for men. By capitalizing on the high-quality ingredients in Daily 3®, adults of all ages can boost their immune support and start to reverse any kind of lack of energy they’re experiencing.

If you’d like more information on basic supplementation and the benefits of taking a daily multivitamin supplement, download our eBook The practical guide to nutritional supplements.

Daily 3® Dosage

For optimal results, we recommend taking three Daily 3® multivitamin supplement capsules — each with 42 high-quality ingredients, including 12 vitamins and 8 minerals — a day. It’s best to always take Daily 3® with food. We recommend taking one capsule with each of your three main meals of the day.

1. Jonscher KR, Stewart MS, Alfonso-Garcia A, et al. Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice. FASEB J. 2017;31(4):1434-1448. doi:10.1096/fj.201600906R
2. Ohwada K, Takeda H, Yamazaki M, et al. Pyrroloquinoline Quinone (PQQ) Prevents Cognitive Deficit Caused by Oxidative Stress in Rats. J Clin Biochem Nutr. 2008;42(1):29-34. doi:10.3164/jcbn.2008005
3. Tarantini S, Valcarcel-Ares MN, Toth P, et al. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019;24:101192. doi:10.1016/j.redox.2019.101192
4. Rahal A, Kumar A, Singh V, et al. Oxidative stress, prooxidants, and antioxidants: the interplay. Biomed Res Int. 2014;2014:761264. doi:10.1155/2014/761264
5. Williams M. Dietary supplements and sports performance: amino acids. J Int Soc Sports Nutr. 2005;2(2):63-67. Published 2005 Dec 9. doi:10.1186/1550-2783-2-2-63
6. Tarantini S, Valcarcel-Ares MN, Toth P, et al. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019;24:101192. doi:10.1016/j.redox.2019.101192
7. Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 2010;285(1):142-152. doi:10.1074/jbc.M109.030130
8. Nakano, Masahiko & Yamamoto, Tetsuro & Okamura, Hisayoshi & Tsuda, Akira & Kowatari, Yasuyuki. (2012). Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep. Funct. Foods Health Dis. 2. 307-324. 10.31989/ffhd.v2i8.81.
9. Rosanoff A, Weaver CM, Rude RK. Suboptimal magnesium status in the United States: are the health consequences underestimated?. Nutr Rev. 2012;70(3):153-164. doi:10.1111/j.1753-4887.2011.00465.x
10. Halder M, Petsophonsakul P, Akbulut AC, et al. Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease. Int J Mol Sci. 2019;20(4):896. Published 2019 Feb 19. doi:10.3390/ijms20040896
11. Theuwissen E, Smit E, Vermeer C. The role of vitamin K in soft-tissue calcification. Adv Nutr. 2012;3(2):166-173. Published 2012 Mar 1. doi:10.3945/an.111.001628